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One thing I have not seen mentioned here is the button which most readers have which increases the size of the text.
If someone uses it because they are older, or don't have their glasses that day, or have to hold it at some distance while on a bus/train, then the layout will change. It almost never changes favorably.
Unless you are in a position where you can force your reader to use a particular large screen device, then you are likely to have some trouble.
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