I think e-ink will only continue to evolve and that flexible substrates rather than glass will lower prices, improve toughness, and provide for a better experience visually for a while.
That said, e-ink is just a display technology, ebooks are not going anywhere, though I'm hopeful that a hybrid between easily scalable tech like PDF/postscript and epubs will occur and allow for the best of both.(Epub 3X maybe?)
I forsee continued progress with speech recognition, both locally on device and with net powered processing for the heavier lifting like context eventually. That said, Google Glass and similar technologies may eventually supplant the e-reader with multipurpse ubiquity. The latest tech seems to be direct projection onto the retina, so who knows?
But, barring a scenario like the "Revolution" TV show is predicated upon, I think ebooks are here to stay. Even then they'd still exist.
OTOH(is that three? -I've lost count...), I can easily imagine a world where paper books become increasing expensive to produce due to fuel costs, deforestation, and possibly a desire on the behalf of some to broaden the gap between the technology we use to read, dream, philosophize, better ourselves and that by which we clean our bottoms... Hey, I may be nuts, but I have a good time.
