I tried it on my Kobo Glo for the heck of it, and it seems to work, I couldn't find any hyphenated words at all.
It did change how bold italics are displayed though, they're no longer bold anywhere in the book. But the Kobo is really touchy about that when <em> is used instead of <b> to denote bold. I had tried adding font-weight: bold to each italic class, but that didn't work. I'd have to go through and probably change the <em> everywhere and see if that will work, but since you're not worried about it on a Kobo, not sure I'll bother, unless you're curious about it for some reason.
But it did seem to eliminate all hyphens and didn't mess up anything else other than Kobo's quirkiness over bold italics.
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