@br
I defrag, but I am not sure how that significantly helps speed in this case.
The only file that might benefit (startup) is metadata.db.
I believe the OP mentioned this is a USB drive. That will slow things down unless it can fully use a USB3 connection)
Make sure that Windows can NOT use this drive for swap (VM),
Exclude this drive from the Indexing Service
Exclude this drives Library folder from Realtime scans, all the files should have been pre-qualified in their original location
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