The reader of your book will see the same thing regardless of which is used.
The only case where I can conceive of this causing a problem is in an academic setting where you are told to use nbsp.
2000 non breaking spaces seems like a lot. Make sure they are used only where they are actually needed to make sure the space is
1. Never deleted by the reading program or device.
2. Two words must be jointed together.
If you are using them to generate vertical space, it is more easily and predictably done in CSS using margin-top or something similar.
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