I have both an e-ink Kindle and a Nexus tablet (with the Kindle app). For me, the respective advantages are:
For the Kindle:
1. Lighter and more comfortable to hold.
2. Much better battery life.
3. Easier navigation (for example, the Back button does what you expect).
For the Nexus:
1. Much better for pictures, charts, photos, etc (for that reason, I generally read magazines and reference books on the Nexus).
2. Faster page turns.
In short, it's all pretty subjective. Everyone must make his or her own decision.
Mike
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