Are you assuming that you'll have eye strain because of an LCD screen? I ask because many people say this and pretty much everyone believes it. I did until I actually started reading on Nexus 7. I actually find the text to crisper on my Nexus 7 as opposed to my old Sony PRS-350. If you find looking at LCD screens for a long period of time to be bothersome then I would simply look at options like Calibre. I registered my Sony Reader and my old Nook with the respective store but only used Calibre to sideload book onto. I wasn't locked into ANY bookstore with Calibre.
I've gotten lazy since I got my tablet because I can shop at all the bookstores via apps but Calibre is great (I need to start using it again).
I agree with the others about Apple being very closed. I mean if that's an issue for you then I'm not sure you want an iPad. Actually, just about every device is going to be closed in some way or another (unless you root it and that isn't for the faint of heart).
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