From my own experience with note-taking, highlighting and annotations on an e-ink device, it is very slow, especially for copious amounts. Maybe things have improved but I'd be skeptical. I used to use my Sony 950 and just as there is a slight pause between changing pages, there was always a slight pause between each step in taking any kind of note. But that wasn't really the bad part as I could deal with that. The bad part is that the more notes/highlights/annotations stored on the e-reader, the slower it became, until it became ridiculously slow to the point of being almost unusable and trying to take a note was like pulling teeth with how slow everything was.
Together with easy access to fast info searches as needed on things I'm reading about (wikipedia, google, etc.), this is the main reason I basically exclusively use a tablet now for e-reading. I would much prefer to read on e-ink but the advantages of the tablet outweigh e-ink.
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