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For the screen if it is really dirty I use a mixture of 50% distilled water mixed with 50% pure isopropyl alcohol. You apply the stuff to a lint free cloth (microfiber is excellent) and gently wipe the screen from the edge towards the middle (so you don't trap gunk under the IR touch edge - for the newer edgeless readers direction doesn't matter).
If it is real leather use saddle soap.
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