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If epub or html is available, you get a giant running start using Sigil.
The only gotcha I would warn you of it that you can NOT undo a global search and replace. So save before each global search and replace so you can go back to the previous one if it goes amok.
One way to avoid too much damage is to select text, then right click to "mark" it. Then you can confine your actions to just one section. If successful, then right click to unmark it.
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