Thank you for all of the suggestions. I do routinely defrag the hard drive, use ccCleaner, etc. Everything else on this computer is working normally, at least for now. The system is a quad core processor with 8GB of RAM.
The metadata.db file is with the library folders on a separate drive from the program. I have a 2 TB hard drive where all of my data lives, including my Calibre libraries. I can access everything normally on this drive, add and rename files, and play videos with no problems or lags. My Calibre libraries are backed up, both to the cloud and to my Raid 0 NAS.
I guess the next step is to close Calibre, move the libraries to a different hard drive, and then point Calibre to the new location.
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