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Margins, indents and font sizes are usually much better done with relative sizes like em or percentages. That way they will scale with the reader.
You can use TTF or OTF, that does not really matter. However, not all fonts render that well on readers. I would advise to check the epub in ADE on the PC to see if the fonts show up. If the font does not render, you should check the OS/2 version mapping in the font (yes, I mean OS/2...). It should be 3 or less.
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