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Not really. ePubs can do images fairly well, and for me, reading on a smaller screen, reflowable and resizeable text trumps pretty layouts. Unless of course the whole point of the book is in the pictures; but I'm assuming that the pictures supplement the information conveyed in the text, which should be central.
Personally, I'd want the data presented in a way I can read and understand it without being irritated or getting an RSI from repeated panning and zooming. Or having to buy new eyeglasses because of eyestrain increasing my prescription. PDFs are evil for all of the above reasons.
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