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The usual size for early ereader screens was 600x800 pixels.
Amazon ask for 300 dpi resolution, but this usually makes the file too big for the ePub spec, so I stick with 72 dpi
Calibre resizes all graphics to 576x768 but by experimenting I have found that on my Sony and Nook anything, except the cover, taller than 740 means the bottom of the picture is obscured.
I agree that the marketing thumbnail is the most important aspect, but I do go backwards from the start point to look at the cover and other pages in books that I buy.
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