You should notice a difference if you close the tag browser window, when editing metadata.
And if you remove custom columns that depend on other fields, and the formats column, then that should make it faster to move from record to record.
You could also try the new database backend. I belive it is much faster for some of the cases mentioned above. But make sure you have a recent backup. It is not released for "production" yet.
You could also split the library. For instance fiction/non-fiction. Also you could create a new small library for a smaller group of books, like a few authors A-B, and fix the metadata for the books while they are in that small library. Then move them back to the main library.
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