First of all - e-ink Kindles don't support Guided View. There is only Panel View support.
And using it require declaring location of every panel. So for homemade MOBI workload to do that is impractical.
If you need Virtual Panel View use our KCC. It jumps from corner to corner with right reading order. But in most of cases it is not needed - Everything is readable without zoom if MOBI file was prepared correctly - Some samples (CC licence) on on our site:
kcc.vulturis.eu
Converting CBR to PDF is perfect method to completely screw your reading experience. That method even don't properly cut white-spaces not even mentioning other image improvements.
About file size - Remember to hit MOBI files created by KindleGen with a KindleStrip. It will decrease file size ~50%.