Don't use fixed sizes like pt, your readers will not be happy. You effectively will kill any scale options. Use relative sizes like percentages and em's.
Your mindset is not going to help you. ALL tools have learning curves.
Due to the reflow character of an ebook, what you want with pictures is not possible, like Jellby already said.
Also, <u> can still be used and will work. Heck, officially <i> is also depreciated.
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