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Yes of course. But in the right way. Styles should be based on function with as less css as possible. Page margins, normal paragraph style, line height and of course fonts should be mine to define. I know, how I want to read. Designers should respect this. This is one of the major advantages of e-Books. I for example read on a 5" reader. And there is a bezel around my reader. No need to throw half my reading space away with big margins, like some designers do. You do not look at a book from arms length away and say: Oh, from here it looks nice. You read it. It should be designed that way.
So here a few examples, what I think is good behaviour for an e-Book (for novels):
The normal paragraph style should be simple. An extra style for first paragraphs after headings and scene breaks is a very good idea.
Use margins only to indicate a special function, like poems or chapter prefaces.
Use scaling not px or inch or something like that. Use percent or em. If you absolutly need to implement a font, do it never on the main body. Headings and special things are okay. And set fallbacks, like monospace or sans-serif.
Thats pretty much it. Simple is better. Make a clean and nice text and let the reader decide the rest.
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