I'd say the first line of defense is run your epub through Adobe Digital Editions software (free) on your desktop. I've found that if a book works well there, it will usually do fine on the major epub reader devices (Sony, Kobo, Nook) and *ALSO* on their Android apps, as well as the Overdrive app.
The next three Android apps that generally do a good job of rendering CSS are Aldiko, Mantano and Bluefire Reader. So if your book looks good in ADE, it should look OK with these apps.
Moon+, FB Reader, Cool Reader and some others do not pick up all the CSS and as a result, books may look a bit wonky. They'll be readable usually, but won't look *as published*. There's not much you can do to control that though, as the reader will use the app they prefer to read with.
Pat's idea of asking your beta tester which app he used is a good one, because at least you can rule out the possibility he used an app that does not have good CSS support.
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