If you experience heavy system load on cold start that will be because the calibre dlls are being loaded into the cache. Once they are cached, it will be fast. Similarly if you wait a long time then the cache is flushed so when you start calibre again, the dlls have to be loaded again.
This problem is particularly severe for calibre because calibre uses non native toolkits for everything, so it does not share dlls with other programs on your computer.
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