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sian is apparently trying to push the ipad mini on every thread at the moment...
If weight is the main criteria, a 5" reader might be best but the Kobo mini was simply dreadful: unresponsive screen, buggy firmware... There are others but I only know of Chinese makers. You probably do not want the hassle...
My grand-mother has trouble with arthritis on her thumbs. She tried using my PRS-505 last winter and, though it was a bit heavy, she found it best to rest it on her wrist and forearm and use her middle or ring finger to reach the buttons on the right side. It has both buttons there (previous and next). Maybe one of the newer readers offers this possibility? Again, I only know of Chinese models...
The bookeen odyssey has both buttons and touch but you need to use it with both hands to use the buttons (at least I do). Their firmware is not on par with Kobo's or Amazon's but it's still quite good (much better than the Kobo mini). It's a bit fussy about the micro sd card. The main concern is their customer service which is apparently dreadful.
The way the buttons are placed on the PRS-T2 suggest that you need to use them with your left thumb. Not good if you can't move it because of arthritis...
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