I just experienced very similar problems. New PRS-505 been working fine for a couple of days, then suddenly started hanging on 'Starting up...' (I hadn't specifically shut it down before this). I fiddled for a bit, turning off and on, then plugged it in via USB in case it was a battery problem (at work, so no charger), and connected successfully. When I unmounted it, it hung on the USB screen for about ten minutes - hit the power switch (not the reset switch) a few times to no effect - then suddenly it came back and all is normal again...
On Mac, haven't used any Sony software with it - although it came pre-installed with stuff from a PR agent, so somebody probably has...
Update: And I just noticed it's lost the place in the book I was reading. Not good.
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