Not sure how that would work for bitmap scan PDFs. k2pdfopt can be parametrized, but KoReader won't help anyway (it's using k2pdfopt internally, so the result is the same). Well, that said: KoReader _does_ have a gamma setting that would allow for *some* adaption. If you use it using a launcher like KUAL you can use it for PDFs only, it has its own file selector (though still a bit rough around the edges). I guess Duokan might also have a gamma setting, but I'm not sure, didn't use Duokan in a long time now. Both options are certainly advanced stuff. Out of the box, I guess mangling the PDF on your PC with software is the only option.
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