I don't use any and I haven't had a virus since the days of windows 98, that said I understand how they hide themselves, were they conceal their startup entries and such so it isn't that hard for me to manually check my system and make sure I recognise everything there.
What I actually do now and again is give a quick scan with malwarebytes anti-malware or if I'm suspicious of something not acting quite right or to be doubly sure I would use the eset online scanner for a quick check.
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