Hitch,
I hold a Black Belt in American Freestyle Karate, I am second yellow in Aikidho, and I have also trained in Sho do khan, and just recently started Kali. I am undefeated in my class in tournament fighting.
I am 180pounds, 5'11" My wife, also black belt and trained in more styles then I have is 5'1" 100 pounds.My 9 year old son is also a black belt, and is training in Aikidho and Kali now with us.
So I have a wide range of sizes to compare. And yes, we fight for fun around my house.
I agree with GMW you are over simplifying it. There are blows that my wife can deliver that will kill an adult man, or disable him. She has a lot less room for error then I do, but I promise you, she can win the fight against a superior sized attacker. Put a weapon in her hand and it just gets better.
The key is that in a real life/death fight - you have seconds at best to win. These Hollywood fights that go on for 16 million hours are total BS. If it comes down to a head on, straight up boxing match, no she does not stand a chance. But if it gets there, she has already lost. A contest of strength she can never win, a contest of timing, speed and skill, she has a chance.
As for this attacker, slashing both jugulars makes a big mess but if you know how to move you can keep the blood off you, and its fast easy and silent. Strength of the attacker/victim will not come in to play, however you will have a problem with reaching, so you may want to consider the femoral instead of the jugular.
A 22 with a silencer would also work well and less chance for error. If I was writing the story, I would go with the 22 and sub sonics + suppressor. Its fast, easy, believable, and realistic. Unless there was some special significance in the way she killed, there is no reason to get fancy, IMO.