I don't think the 3G card would be an issue - they have a rather rudimentary, rock-solid interface to the rest of the units. Though the question what Amazon's servers will make of it is certainly valid.
I'm much more in doubt about the motherboard (and thus: firmware?) and screen/controller combo. The e-ink controllers may need different drivers or even for the same driver they might need different waveform initialization data for the different hardware. Well, trying out will tell, I guess....
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