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Depends on the quality of the PDF versus the EPUB. I can't imagine why a PDF file would ever be preferable over an EPUB that is well-done.
In practice, though, EPUBs often have such bad quality (see archive.org) that people (including myself) prefer to read the book in PDF. Not because of any intrinsic advantage of the PDF format (there is none!) -- only because the EPUB version is so badly done.
EPUB is still very much a "new" format compared to PDF, and it will take some time until publishers start paying proper attention to it. And after they do, no one in their right mind will prefer PDFs over EPUBs; including for studying technical books and textbooks.
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