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I have smallish hands, and I can read on my Kobo Glo one-handed with either hand (tapping with right thumb, or swiping with left). Touch screens might be difficulty if you have a tremor, but otherwise it should be ok.
Even in ambient light, the frontlight really improves contrast/readability. I keep mine always-on at a low level, and it's fantastic. With the Kobo at least, the Glo also has a higher resolution than the Touch. Not sure about the other readers.
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