Well I am not thrilled with the way the vote is going as I have already read Animal Farm and A Study in Scarlet several times. Of the two I would prefer A Study in Scarlet as it would lead to a entertaining discussion.

I am surprised that no one has yet mentioned the film The Seven-Per-Cent Solution, one of the oddest of the on screen adaptions of the Holmes character I have ever seen. Then I have not ever seen many of the others mentioned here. To me Basil Rathbone will always represent Holmes on film, even though everything else about those films was so lame; the bumbling fool of a Watson and the setting in the years (1939 to 1946) that the films were produced. Give me Victorian England Holmes every time.