Thanks for the report... I couldn't understand why it didn't work. anonimo200, it should work everywhere, not just in the PDF reader.
A single contrast change is often subtle, and if there aren't many shades of gray the screen won't even flash. To be sure it's working, push Shift + click the fiveway and it will invert. Also Shift + left twice will go to monochrome mode, which should be obvious e.g. in the status bar at the top of the screen. After that it would also stop flashing between updates.
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