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The majority of the e-ink readers use the mobile version of ADE, so yes, a lot of readers use ADE. You are probably better of with an embedded version, which is totally possible, also with Sigil. The problem is, afak, that Indesign does some akward things.
Also, keep in mind that the OS/2 version of the embedded font must be 3 or lower. Not 4 or automatic.
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