There are no noticeable differences wrt 5.3.2, so it should be safe to update, but you can just as well simply stay with the current version.
For users of jailbroken devices:
The jailbreak stays intact, as do the modifications. (Hey, for once they seem to not have re-obfuscated the Java classes... IOW: first tests indicate that Collections Manager and JBPatch continue to work).
Depending on the amount of customizations, a direct upgrade from a modified 5.3.2 to 5.3.2.1 might still fail, but it's not very likely.
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