Quote:
Originally Posted by theducks
I/O error =Input/Output error = I can't read / write to the designated hard drive 
This is NOT a Calibre specific problem. You are shooting the messenger
There are many reasons this could show (not all are disasters)
1)Your current logon is not the owner of the Library folder. Easy fix. Logon as the owner/change the 'group' rights to RWX
2)  your Library drive is failing
3) you are being blocked by security sowtware
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I don't want to shoot anybody, boss.

We might have crossed paths when I added above: "when I attempted to re-open calibre, I got the "failed to create" library message, noticed that my E: drive had been kicked off, unplugged/replugged the connection and all appears okay now. I guess."
This is a different drive than I had been using before and the connections all seemed secure, so I don't know what was up with that.