You're going to have to provide more information then. How does it crash, what error do you get, what activities trigger the crash. Start calibre in debug mode and post the output. This is caused by a conflict with something on your computer, calibre does not crash spontaneously by itself. You will have to figure out what it is. Start by turning off your antivirus program. Reboot in safe mode and see if the crash can be replicated and so on.
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