I read a lot comis and magazines on my 10" android (xoom, wich is quite old & heavy compared to new ones). Nowadays reading epubs there too since my e-reader no longer is.
I gotta say the weight factor depends a lot on where you read and how, 'cause in the end I use some sort of support reading on the xoom as much as I did when reading on my e-reader. So the weight, to me, is not a matter (just the lcd screen is). I also do enjoy how my reading flows a lot quicker when i have more text per page. >3
And as far as working... what kind of work do you intend to do? I find most applications that are work-productive in tablets aren't the ones that requires really fast processing and such, so the processing power is not a biggie... i would give higher priority to weight/disk space/confortability.
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