do you know which program was used to generate the epub? i'm not totally certain, but feel like i've seen an over-abundance of <span> tags sometimes produced by indesign's export to epub. also completely a wild guess, but perhaps there had been a style applied to the text in indesign, but the indesign style itself contained no information...?
but yes, back up, try removing them all and see if it changes the layout.
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