Multiple passes is the only way once the (book)data is in Calibre.

Tune the Adding Books REGEX to your naming convention, before you add books.

Your
last pass will clean the title.

Use the
Apply button at the end of each Transfer pass.

Write the full REGEX term and use the appropriate back reference in the replace box.
Note: series is a pain (requires 2 passes). The Series NAME must be set before setting the Series_index