Have you checked to see if there are any books stuck indexing (do a search of your items from the home page for non-existent term, like 'zzxyq' and it'll tell you if there any books not yet indexed). This is something that could cause the battery to drain a bit quicker than normal, and it's something that happens with me on occasion when I transfer books to my Kindle using Calibre (not sure why as when I delete the offending book and reload it's fine).
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