Personally, I believe that -as epub grows in popularity- PDF e-book support will become less and less relevant in the future. The only reason e-books get published in PDF nowadays is because it is the format that almost everyone supports.
PDF reflowing shouldn't be a priority imo. Epub support on the other hand should be one of the highest priorities.
and about large pdf files....I have some comics converted to PDF that are easily over 100 meg in size. They take about 10 seconds to load and never crashed on my cybook.
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