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I'm not familiar with the Firefox SQL plugin, but setting a cell's default value is a pretty trivial action; and unless you put in the wrong data type, there's really nothing that can go wrong there.
But it seems the plugin is more aimed that at just looking at the data (and perhaps modifying it a bit), rather than doing actual database management.
If you want to play it safe, get a "real" SQL management tool—otherwise, just go ahead with the plugin, and tell it to do the modification. (After all, even if they screw up, you still have your backup.)
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