Yes, most likely, but no guaranties. You really should have a full backup of all files. You never know.
Try to create a small "fake" library first, to make sure everything works, before you try with files you care about...
I assume that usually the whole metadata.db will automatically be cached in RAM. So the gains may not be very big when you just browse and read. When you update metadata, the speedup may be greater.
Plenty of memory in the computer probably is the best and safest way to speed up Calibre.
Last edited by Adoby; 09-02-2012 at 03:39 AM.