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Hard to tell without knowing the person.
In theory, any reader will work. It's just not that hard to flip a page.
In practice there are tons of issues you didn't think about. For example some readers have very small selection menus for books. So while you can use large font in the book itself, that's no good if the selection menu itself is unusable.
Then some people like to touch the text they read (follow lines with the index finger or whatever), because they easily lose the line otherwise (due to bad sight). So in such a case you'd have to avoid touchscreens whereas other people might love touchscreen.
A 6" screen should be fine, you can still get reasonably large fonts (esp. using landscape mode), sure you have to flip the page more often but so what? I'd consider larger screens only if the sight's really bad. Don't forget that larger devices are also heavier and less comfortable to handle.
But again this depends on the person what he/she prefers. If you have a store that sells eReaders it might be a good idea to just go there with the person in question and let him/her have a go at the devices on display...
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