As far as comics go... I've seen some color comics show up really great in the black & white that the Kindle pretty much does, and I've seen it look really terrible. With the comics I've put on mine, I usually just stick to black & white ones (like The Walking Dead) so that I already know how it's going to look.
I haven't really used Mangle much, I just used Calibre to "convert" them and ship them off to my Kindle. So, hopefully someone else will be able to help you with that.
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