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This is definitely not a behaviour I have seen in several years of heavy use of Calibre and I also use Windows 7 Pro. It sounds as if on your system there is something interfering with Calibre's disk access.
One thing that occurs to me - have you excluded the Calibre library from checking with your Anti-Virus software? I did this to improve performance, and because eBooks are not something that needs checking for a virus.
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