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It'll make so little difference in both terms of performance or wear that I doubt it really matter. Just keep your library defragmented if you're using mechanical disks. Disabling aggressive(or any really) power-saving on them is also a very good idea.
I have my Calibre install on one SSD, library on another with source repos etc - performance of conversion is exactly the same as my mechanical drives (SSD's are Vertex 3's, mech are old Hitachi Deskstars which are well looked after), startup times are likely fractionally lower but not enough to care about. Can't think of anything else that would really be disk limited in some way.
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