@lauraine - welcome to MobileRead.
I'm going to take a guess and say that you mean you upgraded to the latest version of calibre, not of this particular Modify ePub plugin? You are going to have to be more specific with the details of "what won't open", the exact actions you are trying etc for anyone to be able to help you.
It sounds to me like your question should be moved into its own thread once it is confirmed your question is unrelated to the Mdify ePub plugin.
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