Hey guys!
Because I have too have a transformer prime I was searching quite long for a solution or workaround.
Bad news: Like said in the posts before there is no solution

Good news: I created a workaround! Its a little selfcoded software which can connect calibre with your transformer prime. Until now it is only one way (calibre->tfp) but I am still trying to make it both ways.
What you need on your device is:
USB-Debuging - ON
Busybox installed
You don't need administrative privileges but they aren't bad either.
Until now tested on Win7 x64 and tfp with android 4.0.3
http://rapidgator.net/file/18802118/...TF201.rar.html
All you need to do is:
-unpack the archive into a folder
-choose the x32 file for Win 32-bit or x64 file for Win 64-bit
The other one you can delete!
-edit the Settings.ini until it fits your taste
(Edit: The folders you edit in the .ini have to exist already!!!)
-start the program
-click yes at both messageboxes
-follow the howto by clicking on the new icon in the taskbar and choosing howto
-plugin your device
-use calibre like you would do it with each other device!!!
Hope you like the program! Feedback would be great!