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Someone with arthritis or joint issues might not be able to prop it up the way you and I do. Not being a pain here, but when you start talking about mobility issues and joints and the like, things can get painful and tricky fast. It might be too challenging for someone to have to lift up a pillow to prop a larger device up while holding a light weight e-reader is not as much of a problem.
My Mom loves her DX and would not want a smaller Kindle. She prefers the larger screen and is able to handle the larger size. Some of her friends would not be able to. It really is a very personal decision. Also, it is a lot asier to carry a 6 inch e-reader in your purse to appointments and the like than an IPad. The weight does add up over time.
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