I don't see the use case for it? Why would you blindly want to do search/replace operations across your ePubs? For me search/replace is something I do in an editor like Sigil, as context is usually important. Surely you need to look at the document first to figure out what you are going to search for?
To answer your other question, yes it would be a lot of work.
You obviously have some scenario/situation in mind...?
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