For a bit of fun, I tried plugging my year's books into a spreadsheet for the decades and letters, to see how I was doing. On the years, not bad at all. I'm missing the 1900s, 1930s, 1980s and 1990s. The latter two will undoubtedly happen naturally - I'm in the middle of an 80s book already - but the 1900s and 1930s might need a bit more work.
The letters of the alphabet is a bit more problematic, though. I'm still missing more than half of the alphabet, and there just isn't enough choice for some letters. Particularly X and Q. (I'm actually okay with Z - I have a Roger Zelazny in my in-tray, and might already have read a short by Timothy Zahn.) I doubt I will specifically pursue either target, but I am considering publishing my own book under a pen-name beginning wih X.